FTA DMPK-IND Cards

• DBS microvolume sampling requires only 10 to 20 μl per sample.
• Fewer experimental animals are required because Toxicokinetic data are derived from Toxicology animals, thereby eliminating satellite colonies.
• More consistent data are obtained through more serial sampling from individual animals and less reliance on composite data.
• The 3-step DBS procedure is much more straightforward than the cumbersome centrifugation, isolation and cleanup of plasma.
• On-substrate cleanup has the potential to convey greater analyte stability, especially for enzyme-sensitive compounds.
• Room temperature stability saves on cost of dry ice shipments.
• Shipping without dry ice allows more remote sampling.

The FTA DMPK-A and FTA DMPK-B cards lyse cells and denature proteins on contact. Samples can be shipped and stored at ambient temperature and long-term stability has been demonstrated for analytes and metabolites sensitive to plasma enzymes.

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